Thrombotic Complications in Patients Infected with HIV in the Era of Highly Active Antiretroviral Therapy: A Case Series
Identifieur interne : 008888 ( Main/Exploration ); précédent : 008887; suivant : 008889Thrombotic Complications in Patients Infected with HIV in the Era of Highly Active Antiretroviral Therapy: A Case Series
Auteurs : Michael C. Jacobson [États-Unis] ; Bruce J. Dezube [États-Unis] ; David M. Aboulafia [États-Unis]Source :
- Clinical Infectious Diseases [ 1058-4838 ] ; 2004-10-15.
Abstract
Background. Recent reports suggest that patients infected with human immunodeficiency virus (HIV) may have an increased risk of developing thrombosis, but the etiology, risk factors, and clinical course remain largely undefined, with few descriptive case series. Methods. We identified 30 patients from an HIV outpatient clinic (treatment population, 650 persons) who had had a total of 43 venous or arterial thromboses during 1996–2002. Data pertaining to demographic characteristics, medical history, thrombosis presentation, and clinical outcomes were abstracted from patient medical records. Results. The median patient age at the time of thrombosis was 43 years. Although the presence of persistent antibody to phospholipids was the most common abnormal finding in the laboratory, evaluation of thrombophilia, cases of low levels of proteins C and S and antithrombin III, and elevated levels of factor VIII and homocysteine were also identified. Seventy-seven percent of the patients smoked cigarettes, 57% had dyslipidemia, and 43% had a malignancy (most commonly Kaposi sarcoma). Although the Centers for Disease Control and Prevention (CDC) classification for 16 patients (53%) was C3, most showed evidence of immune reconstitution (median CD4 cell count, 290 cells/µL) and control of the virus (median HIV load, 2290 copies/mL). Lower extremity, deep vein thrombosis and pulmonary emboli accounted for 66% of all thrombotic events. The median time to diagnosis of thrombosis was 1 day (range, 3 h to 3 weeks). Conclusions. Patients in this series were characterized by a relatively young age at the time of thrombosis, a predominance of elevated levels of lipids, a history of malignancy, and an advanced CDC HIV classification but not by a low CD4 cell count or an elevated HIV load.
Url:
DOI: 10.1086/424664
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003774
- to stream Istex, to step Curation: 003774
- to stream Istex, to step Checkpoint: 001D70
- to stream Main, to step Merge: 008B50
- to stream Main, to step Curation: 008888
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Thrombotic Complications in Patients Infected with HIV in the Era of Highly Active Antiretroviral Therapy: A Case Series</title><author><name sortKey="Jacobson, Michael C" sort="Jacobson, Michael C" uniqKey="Jacobson M" first="Michael C." last="Jacobson">Michael C. Jacobson</name></author><author><name sortKey="Dezube, Bruce J" sort="Dezube, Bruce J" uniqKey="Dezube B" first="Bruce J." last="Dezube">Bruce J. Dezube</name></author><author><name sortKey="Aboulafia, David M" sort="Aboulafia, David M" uniqKey="Aboulafia D" first="David M." last="Aboulafia">David M. Aboulafia</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:76C84C20E01604E120A9FBA3D908BA218C2DE2AF</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1086/424664</idno><idno type="url">https://api.istex.fr/document/76C84C20E01604E120A9FBA3D908BA218C2DE2AF/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">003774</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003774</idno><idno type="wicri:Area/Istex/Curation">003774</idno><idno type="wicri:Area/Istex/Checkpoint">001D70</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001D70</idno><idno type="wicri:doubleKey">1058-4838:2004:Jacobson M:thrombotic:complications:in</idno><idno type="wicri:Area/Main/Merge">008B50</idno><idno type="wicri:Area/Main/Curation">008888</idno><idno type="wicri:Area/Main/Exploration">008888</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Thrombotic Complications in Patients Infected with HIV in the Era of Highly Active Antiretroviral Therapy: A Case Series</title><author><name sortKey="Jacobson, Michael C" sort="Jacobson, Michael C" uniqKey="Jacobson M" first="Michael C." last="Jacobson">Michael C. Jacobson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington School of Medicine, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Dezube, Bruce J" sort="Dezube, Bruce J" uniqKey="Dezube B" first="Bruce J." last="Dezube">Bruce J. Dezube</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Aboulafia, David M" sort="Aboulafia, David M" uniqKey="Aboulafia D" first="David M." last="Aboulafia">David M. Aboulafia</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>University of Washington School of Medicine, Seattle</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Virginia Mason Medical Center, Seattle</wicri:cityArea></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical Infectious Diseases</title><title level="j" type="abbrev">Clinical Infectious Diseases</title><idno type="ISSN">1058-4838</idno><idno type="eISSN">1537-6591</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published" when="2004-10-15">2004-10-15</date><biblScope unit="volume">39</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1214">1214</biblScope><biblScope unit="page" to="1222">1222</biblScope></imprint><idno type="ISSN">1058-4838</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1058-4838</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background. Recent reports suggest that patients infected with human immunodeficiency virus (HIV) may have an increased risk of developing thrombosis, but the etiology, risk factors, and clinical course remain largely undefined, with few descriptive case series. Methods. We identified 30 patients from an HIV outpatient clinic (treatment population, 650 persons) who had had a total of 43 venous or arterial thromboses during 1996–2002. Data pertaining to demographic characteristics, medical history, thrombosis presentation, and clinical outcomes were abstracted from patient medical records. Results. The median patient age at the time of thrombosis was 43 years. Although the presence of persistent antibody to phospholipids was the most common abnormal finding in the laboratory, evaluation of thrombophilia, cases of low levels of proteins C and S and antithrombin III, and elevated levels of factor VIII and homocysteine were also identified. Seventy-seven percent of the patients smoked cigarettes, 57% had dyslipidemia, and 43% had a malignancy (most commonly Kaposi sarcoma). Although the Centers for Disease Control and Prevention (CDC) classification for 16 patients (53%) was C3, most showed evidence of immune reconstitution (median CD4 cell count, 290 cells/µL) and control of the virus (median HIV load, 2290 copies/mL). Lower extremity, deep vein thrombosis and pulmonary emboli accounted for 66% of all thrombotic events. The median time to diagnosis of thrombosis was 1 day (range, 3 h to 3 weeks). Conclusions. Patients in this series were characterized by a relatively young age at the time of thrombosis, a predominance of elevated levels of lipids, a history of malignancy, and an advanced CDC HIV classification but not by a low CD4 cell count or an elevated HIV load.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>Washington (État)</li></region></list><tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Jacobson, Michael C" sort="Jacobson, Michael C" uniqKey="Jacobson M" first="Michael C." last="Jacobson">Michael C. Jacobson</name></region><name sortKey="Aboulafia, David M" sort="Aboulafia, David M" uniqKey="Aboulafia D" first="David M." last="Aboulafia">David M. Aboulafia</name><name sortKey="Aboulafia, David M" sort="Aboulafia, David M" uniqKey="Aboulafia D" first="David M." last="Aboulafia">David M. Aboulafia</name><name sortKey="Dezube, Bruce J" sort="Dezube, Bruce J" uniqKey="Dezube B" first="Bruce J." last="Dezube">Bruce J. Dezube</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 008888 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 008888 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:76C84C20E01604E120A9FBA3D908BA218C2DE2AF
|texte= Thrombotic Complications in Patients Infected with HIV in the Era of Highly Active Antiretroviral Therapy: A Case Series
}}
| This area was generated with Dilib version V0.6.31. |  |